P11390-001 HPE ProLiant ML350 Xeon Processors Mainboard Gen10 Server.

The HPE P11390-001 is the official system board (mainboard / motherboard) used in the HPE ProLiant ML350 Gen10 series — a versatile tower/server platform built for mixed workloads, virtualization and on-premises edge-to-core deployments. This board is the structural and electrical backbone of the ML350 Gen10 family: it provides CPU sockets, DIMM channels, PCIe expansion lanes, onboard management, storage connectivity and the signaling required by power and cooling systems. The P11390-001 spare part identifier (system board assembly) corresponds to HPE’s Gen10 ML350 design and is frequently referenced by service manuals and parts lists when replacing or refurbishing ML350 Gen10 servers.

Key technical capability highlights

The ML350 Gen10 system board was engineered with scalability, availability and security in mind. At the board level you will typically find support for dual-socket Intel Xeon Scalable processors, an enterprise-class chipset, a rich set of PCIe slots and numerous DIMM sockets for high memory capacity — making the platform suitable for database, virtualization, and I/O intensive workloads. Below are the most important capability areas that buyers, technicians and system integrators pay attention to when comparing or replacing this board.

Processor and chipset compatibility

The ML350 Gen10 system board is built to support Intel Xeon Scalable family CPUs (first and second generation where applicable depending on firmware and SKU). In practice this means dual-socket support for a broad range of Bronze/Silver/Gold/Platinum processors — enabling configurations from low-power entry units up to high-core-count, high-TDP servers for heavy compute tasks. The board routes appropriate UPI links, power delivery and CPU-to-chipset lanes to the C620-series enterprise chipset used on Gen10 systems.

Memory architecture and capacity

One of the ML350 Gen10’s strengths is memory scale: the system board exposes multiple DIMM slots per socket (commonly up to 24 DIMMs in total for two sockets, depending on the exact ML350 sub-model and chassis). This design supports HPE DDR4 SmartMemory in RDIMM or LRDIMM types at server-grade speeds (various JEDEC speeds supported depending on processor, DIMM population and firmware). With the right processor family and high-capacity DIMMs, total system memory can scale to multiple terabytes in enterprise configurations. HPE documentation describes supported memory population rules and maximum capacities—critical reading for large-memory deployments.

Storage and I/O connectivity

The P11390-001 mainboard is designed to integrate with HPE’s configurable storage backplanes and integrated storage controllers. Typical ML350 Gen10 configurations permit a mixture of SATA/SAS HDDs, SATA SSDs and NVMe storage (with front bay NVMe support on NVMe-capable chassis and carrier assemblies). Internal M.2 or internal SATA options for boot devices are available depending on the server configuration. The board exposes multiple PCIe lanes allowing host RAID controllers, HBAs, NICs and accelerator cards (GPUs, FPGAs) to be added. Practical system builds often pair onboard controllers with HPE Smart Array or P-series RAID cards for redundancy and performance.

Detailed subcomponents and features

Power delivery, thermal design and chassis integration

The system board provides the connection points and telemetry for the ML350’s power supplies and thermal sensors. Design considerations on the board include:

• Dedicated power connectors and power-good signals for single or redundant PSU configurations.
• Integrated fan headers and thermal sensor circuits that integrate with HPE’s thermal management algorithms (BIOS/firmware controlled).
• Placement of heatsink mounts and CPU retention mechanisms to accommodate heavy-duty heat sink assemblies required by high-wattage Xeon processors.

PCIe expansion and slot layout

The ML350 Gen10 board exposes multiple full-height/full-length and low-profile expansion slots. The precise count and lane allocation vary by chassis and riser kit, but common layouts are designed to maximize PCIe Gen3 (or later) bandwidth for I/O-intensive cards. Typical expansion uses include:

• Network interface cards (1GbE/10GbE/25GbE/40GbE depending on NIC).
• RAID controllers and HBAs for external SAN or internal RAID arrays.
• Accelerator cards (GPU or FPGA) in mixed workloads.

Onboard networking and management

HPE places an emphasis on manageability. The P11390-001 board integrates the iLO management controller (iLO 5 on Gen10 systems) and has onboard NIC ports (the quantity and speed depend on the exact ML350 configuration). iLO provides:

• Remote console and virtual media capabilities for out-of-band management.
• Firmware security features such as secure boot and a security root of trust.
• Health monitoring, power metering and firmware update orchestration.

These integrated management features are essential for remote troubleshooting and automation in data center environments.

TPM, firmware and security

The system board supports TPM 2.0 modules and HPE-specific security functionality (including signed firmware and secure erase options). These capabilities dovetail with HPE’s broader security initiatives (firmware hardening, iLO security dashboards and Server Configuration Lock) to reduce attack surface and simplify compliance workflows.

BIOS, firmware and driver support

Firmware compatibility is central to successful deployment: BIOS revisions, iLO firmware and firmware for storage and NIC controllers must be kept in sync with the system board’s generation. HPE publishes driver packages and firmware bundles for the ML350 Gen10 on its support site and these packages reference the correct system board assemblies and FRUs. Always match firmware versions to HPE’s published compatibility matrices to avoid unexpected behavior.

Installation, replacement and serviceability

Identifying the correct spare: P11390-001 vs similar FRUs

When ordering a replacement system board, verify the spare and assembly numbers printed on the original board or the server service tag. The P11390-001 identifier is commonly used by HPE and third-party parts vendors to describe the ML350 Gen10 system board; alternate assembly numbers like 874585-002 may also appear in service documentation or vendor listings. Confirm cross-reference numbers before purchase to ensure mechanical and electrical compatibility. :contentReference[oaicite:7]{index=7}

Tools, ESD and preparation

Replacing the system board is a hands-on activity requiring anti-static precautions, proper screwdrivers and a documented parts list. Recommended preparatory steps include:

• Record the server serial and current firmware versions (BIOS, iLO, RAID firmware).
• Back up configuration data and (if possible) use HPE utilities to capture system configuration profiles.
• Disconnect power and external devices and follow HPE’s maintenance manual step-by-step to avoid connector damage.

Common service tasks

Technicians commonly perform these actions around the system board:

• Replacing a failed board with the P11390-001 and restoring the previous server configuration.
• Installing or reseating CPU(s), DIMMs and expansion cards when migrating servers.
• Updating the firmware immediately after board replacement to ensure full compatibility with installed components.

Practical configuration examples

Typical server configurations you will encounter include:

• Entry performance: single or dual Xeon Silver CPUs, 32–128GB RAM, SATA boot drive and a software RAID.
• Virtualization host: dual Xeon Gold/Platinum, 256GB–1TB RAM, NVMe or SAS storage arrays, dual 10GbE NICs.
• Storage-accelerated compute: NVMe front-end with PCIe-based RAID or NVMe-oF adapters and additional HBAs.

Performance tuning and advanced use cases

BIOS tuning and power profiles

To extract deterministic performance, system administrators tweak BIOS settings such as power profiles, NUMA affinity, C-States and Turbo modes. HPE’s server BIOS menus expose settings optimized for either maximum throughput (workloads such as databases and HPC) or energy-efficient operation (branch offices, test labs). Always test changes in a non-production environment and document the result. :contentReference[oaicite:9]{index=9}

Virtualization and dense multi-VM hosting

The ML350 Gen10 with the P11390-001 board is a solid candidate for small-to-medium virtualization clusters. When sizing hosts, consider:

• CPU core counts and hyperthreading for vCPU capacity.
• Memory per host in relation to VM footprint and swapping thresholds.
• Network throughput and latency requirements for VM migration and storage traffic.

GPU and accelerator deployments

If planning to add GPUs or accelerators, verify riser availability and power headroom. Some ML350 configurations and riser kits support full-height GPUs but may require additional power supply capacity or specific cable routing. Consult HPE configurator notes to ensure the board, riser and chassis combination will physically and electrically support the card.

Common failure modes and remedies

• No POST / no video: reseat DIMMs/CPUs and check power delivery; swap known-good PSU.
• Intermittent reboots: confirm BIOS firmware, update iLO and examine cooling and thermal throttling.
• Drive not detected: verify backplane connection, controller firmware and cable seating.

Refurbished boards vs OEM new parts

P11390-001 system boards are available as new OEM spare parts and as professionally refurbished units from third-party suppliers. Refurbished boards can be cost-effective for out-of-warranty hardware refreshes, but validate:

• Return policy and warranty period.
• Whether the board includes necessary attached components (e.g., standoffs, connectors) or is “board only”.
• Seller reputation and testing procedures (burn-in, POST verification, firmware baseline).

Vendor listings and reseller pages often list whether the board is tested and include cross-references to assembly numbers like 874585-002. Confirm those assembly numbers to prevent misorders.

Reading FRU labels and assembly stamps

The system board typically has one or more stickers and silkscreen markings that include the spare part number, assembly number and barcodes. Look for:

• HPE spare part number: P11390-001 (or manufacturer cross reference).
• Assembly number printed on the PCB (e.g., 874585-002 on some listings).
• Silkscreened revision codes or date stamps that indicate board revision.

Photograph the existing board before removal — this speeds accurate reinstallation and helps confirm cabling and orientation.